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Host lncRNAs regulate the transcription factor activities as a scaffold, decoy or posttranslational modification shield. NRON inhibits the activation/dephosphorylation of NFAT as a component of the scaffold complex. Lethe interacts with RelA to repress the transcription activity of NF‐κB. lnc‐DC directly binds with STAT3, prevents the dephosphorylation of STAT3 by SHP1, and activates STAT3‐dependent transcription.
