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. 2018 Feb 2;65(3):660–675. doi: 10.1111/tbed.12823

Table 1.

Outcome following experimental infection with North American swine enteric coronavirus isolatesa

Age Primary clinical outcome Duration of clinical signs Mortality Duration of sheddingb References
PEDV 1 dc 100% severe diarrhoea 18 hpid ND 12 hpid Madson et al., (2015)
10–35 dc 100% severe watery diarrhoea 25 hpid ND 24 hpid Jung et al., (2014)
3 w 70% watery diarrhoea, reduced ADG, emesis 2–10 dpi 0% 1–24 dpi Madson et al., (2014)
3 w Depression, inappetence, diarrhoea, emesis 1–11 dpi 0% 1–18 dpi Pasick et al., (2014)
4 w 30% watery diarrhoea, ±emesis, dehydration 3–8 dpi 0% 2–28 dpi Niederwerder et al., (2016)
4 we 100% mild‐moderate diarrhoea 2–9 dpi 0% 1–42 dpi Crawford et al., (2015)
5 w Reduced ADG 0–7 dpi 0% 1–5 dpi Curry et al., (2017)
Gilts Reduced ADG 0–7 dpi 0% ND Schweer, Schwartz et al., (2016)
PDCoV 2–4 d 100% diarrhoea, ±emesis, dehydration, lethargy 2–12 dpi 27% 2–21 dpi Vitosh‐Sillman et al., (2016)
5 d 100% profuse watery diarrhoea 2–7 dpi 0% 2–7 dpi Chen et al., (2015)
10 d 100% severe watery diarrhoea 1–10 dpi 0% 1–21 dpi Ma et al., (2015)
10 dc Moderate diarrhoea, ±emesis 3 dpid ND 1 dpid Ma et al., (2015)
19 dc 100% severe watery diarrhoea, emesis 1 dpid ND 1 dpid Ma et al., (2015)
5 w No morbidity None 0% 2–5 dpi Curry et al., (2017)
Dams 100% diarrhoea, inappetence 3–9 dpi 0% 2–35 dpi Vitosh‐Sillman et al., (2016))
a

Key: PEDV, porcine epidemic diarrhoea virus; PDCoV, porcine deltacoronavirus; d, days; w, weeks; m, months; ADG, average daily gain; dpi, day post‐infection; hpi, hour post‐infection; ND, not determined.

b

Length of shedding reported as the first and last positive faecal sample or swab in the group.

c

Caesarean‐derived colostrum‐deprived or gnotobiotic pigs used for inoculation.

d

Timing is first detection of clinical disease or faecal shedding; pigs were euthanized and not followed to assess duration.

e

Pigs were exposed through direct contact with an inoculated pig.

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