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. 2005 Sep 5;6(11):967–977. doi: 10.1111/j.1600-0854.2005.00339.x

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Schematic representation of the Flavivirus genome organization and polyprotein‐processing events associated with replication. Cleavage sites depicted with a ▾ represent cleavage by host‐signal peptidase within the lumen of the endoplasmic reticulum. Sites represented with a depict cleavage by the viral‐encoded protease NS3 with cofactor NS2B. The cleavage between NS1 and NS2A is currently not well understood but is performed by a host‐cell protease in the lumen of the endoplasmic recticulum.

Inline graphic — Schematic representation of the Flavivirus genome organization and polyprotein‐processing events associated with replication. Cleavage sites depicted with a ▾ represent cleavage by host‐signal peptidase within the lumen of the endoplasmic reticulum. Sites represented with a depict cleavage by the viral‐encoded protease NS3 with cofactor NS2B. The cleavage between NS1 and NS2A is currently not well understood but is performed by a host‐cell protease in the lumen of the endoplasmic recticulum.