Table 1.

Symptom improvements for seropositive patients treated with 600 mg and 900 mg latiglutenase. Data was analyzed according to equation (1) for weeks 6 and 12 of the study. Values of p ≤ 0.05 are noted in bold.

900 mg
Week 6	Abdominal Pain				Bloating				Tiredness				Constipation (CSBM)
	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value
Seropositive	33.9%	0.165	13.9%	0.445	41.6%	0.021	12.2%	0.364	24.9%	0.070	19.1%	0.074	23.2%	0.487	23.0%	0.230
Seronegative	3.4%	0.946	5.6%	0.771	4.5%	0.817	10.8%	0.364	9.6%	0.451	6.8%	0.422	−41.9%	0.675	−2.7%	0.785
Total	16.9%	0.314	8.8%	0.478	19.8%	0.094	10.1%	0.267	16.1%	0.075	11.6%	0.072	−11.8%	0.928	6.8%	0.599
Week 12	Abdominal Pain				Bloating				Tiredness				Constipation (CSBM)
	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value
Seropositive	57.5%	0.038	38.9%	0.034	44.1%	0.023	19.0%	0.189	20.6%	0.164	9.1%	0.391	104.4%	0.049	37.7%	0.036
Seronegative	−38.7%	0.075	−12.2%	0.263	2.7%	0.929	13.7%	0.402	15.4%	0.264	16.5%	0.092	−22.1%	0.824	3.5%	0.779
Total	5.6%	0.943	7.4%	0.625	18.5%	0.196	14.7%	0.170	17.2%	0.081	13.4%	0.068	36.0%	0.262	17.2%	0.115

600 mg
Week 6	Abdominal Pain				Bloating				Tiredness				Constipation (CSBM)
	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value
Seropositive	24.7%	0.165	17.1%	0.141	29.3%	0.040	10.1%	0.317	23.4%	0.028	16.7%	0.038	46.9%	0.197	−12.1%	0.778
Seronegative	4.3%	0.927	−2.9%	0.633	2.9%	0.923	4.7%	0.712	−13.5%	0.125	−14.3%	0.049	−76.7%	0.949	−5.4%	>0.999
Total	13.5%	0.301	5.7%	0.555	14.2%	0.160	6.4%	0.404	2.9%	0.604	−0.1%	0.926	4.5%	0.505	−8.3%	0.866
Week 12	Abdominal Pain				Bloating				Tiredness				Constipation (CSBM)
	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value	Severity	p-value	Freq.	p-value
Seropositive	48.0%	0.026	28.3%	0.039	31.1%	0.040	6.3%	0.521	36.9%	0.002	22.0%	0.012	43.0%	0.252	−9.9%	0.790
Seronegative	−10.0%	0.532	−9.7%	0.303	11.4%	0.552	5.2%	0.769	−2.6%	0.742	−6.8%	0.403	−41.8%	0.726	2.1%	0.534
Total	17.9%	0.282	6.7%	0.551	19.6%	0.086	5.4%	0.542	14.8%	0.059	6.4%	0.280	8.7%	0.324	−3.4%	0.793