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. 2020 Mar 16;45(6):1673–1684. doi: 10.3892/ijmm.2020.4539

Figure 1.

Figure 1

RES attenuates cell apoptosis induced by HDM. (A) Schematic illustration of an experimental protocol for sensitization of cells by HDM, as well as an experimental protocol for mice pre-treated with RES. (B) Representative images of hematoxylin and eosin-stained lung tissue sections (magnification, ×200). (C) Quantification of inflammatory cell infiltration in lungs. (D) Representative images of the TUNEL assay. Analysis of apoptosis by using TUNEL assay. (E) Quantification of TUNEL-positive cells. (F) Expression of cleaved caspase-3 was determined by western blot analysis. (G) Relative changes in the density of cleaved caspase-3 (n=3). Each point represents an individual mouse. Data are presented as mean ± standard deviation. **P<0.01 and ***P<0.001, determined by one-way analysis of variance with Tukey-Kramer test. RES, resveratrol; HDM, house dust mites; i.n., intranasal; TUNEL, terminal deoxynu-cleotidyl-transferase-mediated dUTP nick end labelling.