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. 2020 Mar 17;45(6):1825–1837. doi: 10.3892/ijmm.2020.4544

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Copyright: © Cai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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EP4 agonism protects liver function in a dose-dependent manner. (A) H&E staining of livers collected after 6 h of reperfusion (magnification, ×100). (B) Molecular structure of CAY, a highly specific EP4 receptor agonist. (C) Bar graphs indicating the percentages of necrotic cells measured in H&E-stained liver sections from animals that received the EP4 agonist at different doses. The highest dose (10 mg/kg at 2.5, 0.5 and 0 h before reperfusion) was the most effective against hepatic injury. The results indicated a dose-dependent decrease in necrosis. n=6. ^*P<0.05 vs. I/R. I/R, ischemia/reperfusion; EP4, prostaglandin E receptor subtype 4; H&E, hematoxylin and eosin; CAY, CAY10598.