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Radiation dose rates and therapeutic indices for [177Lu]Lu-DOTA-PEG7-Tz calculated based on the biodistribution data from the huA33-TCO/[64Cu]Cu-SarAr-Tz/[177Lu]Lu-DOTA-PEG7-Tz pretargeting experiment.
| Organ | Dose (cGy/MBq) | Therapeutic Index |
|---|---|---|
| Tumor | 310.2 | _ |
| Blood | 25.0 | 12.4 |
| Heart | 5.7 | 54.9 |
| Lungs | 11.7 | 26.5 |
| Liver | 11.7 | 26.5 |
| Spleen | 7.2 | 43.0 |
| Stomach | 2.4 | 131.2 |
| S. Intestine | 3.5 | 87.7 |
| L. Intestine | 2.5 | 124.7 |
| Kidneys | 10.6 | 29.3 |
| Muscle | 2.3 | 134.1 |
| Bone | 4.8 | 65.3 |
