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. 2020 Mar 31;45(6):1888–1908. doi: 10.3892/ijmm.2020.4560

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Hsp90 functional inhibition on the levels of myocardial injury and apoptosis. (A) Effect of Hsp90 functional inhibition on physiological indices, such as heart rate, respiratory rate and blood oxygen saturation, and enzymes activities associated with myocardial damage. (B) Representative images showing H&E staining for histopathological examination and its scores. Panels a-d represent the Con, GA, HS, and GA + HS groups, respectively. Arrows indicate swelling cells and degeneration, arrowheads point to hemorrhage, and asterisks mark necrosis and myofiber rupture. Scale bar=100 µm. Effect of Hsp90 functional inhibition on the levels of myocardial injury and apoptosis. (C) Effect of Hsp90 functional inhibition on the cyt c and caspase-3 levels in heart tissues. (D) Apoptosis rate of myocardial cells under different treatments. The relative abundance of all proteins was normalized to that of β-actin. All the results are expressed as the mean ± SD; n=5. ^*P<0.05 and ^**P<0.01 vs. Con, ^#P<0.05 and ^##P<0.01 vs. ASA + HS, and the comparison between ASA and HS is indicated by ^&&P<0.01.

Effect of Hsp90 functional inhibition on the levels of myocardial injury and apoptosis. (A) Effect of Hsp90 functional inhibition on physiological indices, such as heart rate, respiratory rate and blood oxygen saturation, and enzymes activities associated with myocardial damage. (B) Representative images showing H&E staining for histopathological examination and its scores. Panels a-d represent the Con, GA, HS, and GA + HS groups, respectively. Arrows indicate swelling cells and degeneration, arrowheads point to hemorrhage, and asterisks mark necrosis and myofiber rupture. Scale bar=100 µm. Effect of Hsp90 functional inhibition on the levels of myocardial injury and apoptosis. (C) Effect of Hsp90 functional inhibition on the cyt c and caspase-3 levels in heart tissues. (D) Apoptosis rate of myocardial cells under different treatments. The relative abundance of all proteins was normalized to that of β-actin. All the results are expressed as the mean ± SD; n=5. ^*P<0.05 and ^**P<0.01 vs. Con, ^#P<0.05 and ^##P<0.01 vs. ASA + HS, and the comparison between ASA and HS is indicated by ^&&P<0.01.