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. 2020 Mar 31;45(6):1888–1908. doi: 10.3892/ijmm.2020.4560

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Hsp90 functional inhibition on the mitochondrial and cytosolic levels of Hsp90 and associated proteins, and the oxidation levels and function of myocardial mitochondria. (A) Representative western blotting results of mitochondrial Hsp90, Akt, p-Akt, PKM2, Bcl-2 and p-Bcl-2 are shown, and the ratios of phosphorylated/total protein abundance are also presented. (B) Representative western blotting results of mitochondrial cyt c, and cytosolic cyt c and caspase-3 are shown. (C) Effects of Hsp90 functional inhibition on the oxidation levels of myocardial mitochondria. (D) Effects of Hsp90 functional inhibition on the myocardial mitochondria. The relative abundance of all proteins was normalized to that of β-actin. All the results are expressed as the mean ± SD; n=5. ^*P<0.05 and ^**P<0.01 vs. Con, ^#P<0.05 and ^##P<0.01 vs. ASA + HS, and the comparison between ASA and HS is indicated by ^&&P<0.01.