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. 2020 Mar 31;45(6):1888–1908. doi: 10.3892/ijmm.2020.4560

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Akt activation inhibition on the levels of myocardial injury and cell apoptosis. (A) The changes in the heart rate, respiratory rate, blood oxygen saturation and serum enzymes levels in response to TR. (B) Representative H&E staining images of experimental mouse heart tissues and pathological scores. Panels a-d represent the Con, TR, HS, and TR + HS groups, respectively. Arrows indicate swelling cells and degeneration, arrowheads point to hemorrhage, and asterisks mark necrosis and myofiber rupture. Scale bar=100 µm. Effect of Akt activation inhibition on the levels of myocardial injury and cell apoptosis. (C) Effect of Akt activation inhibition on the cyt c and caspase-3 levels in heart tissues. (D) The apoptotic rate of myocardial cells under different treatments. The relative abundance of all proteins was normalized to that of β-actin. All the results are expressed as the mean ± SD; n=5. ^*P<0.05 and ^**P<0.01 vs. Con, ^#P<0.05 and ^##P<0.01 vs. ASA + HS, and the comparison between ASA and HS is indicated by ^&P<0.05 and ^&&P<0.01.

Effect of Akt activation inhibition on the levels of myocardial injury and cell apoptosis. (A) The changes in the heart rate, respiratory rate, blood oxygen saturation and serum enzymes levels in response to TR. (B) Representative H&E staining images of experimental mouse heart tissues and pathological scores. Panels a-d represent the Con, TR, HS, and TR + HS groups, respectively. Arrows indicate swelling cells and degeneration, arrowheads point to hemorrhage, and asterisks mark necrosis and myofiber rupture. Scale bar=100 µm. Effect of Akt activation inhibition on the levels of myocardial injury and cell apoptosis. (C) Effect of Akt activation inhibition on the cyt c and caspase-3 levels in heart tissues. (D) The apoptotic rate of myocardial cells under different treatments. The relative abundance of all proteins was normalized to that of β-actin. All the results are expressed as the mean ± SD; n=5. ^*P<0.05 and ^**P<0.01 vs. Con, ^#P<0.05 and ^##P<0.01 vs. ASA + HS, and the comparison between ASA and HS is indicated by ^&P<0.05 and ^&&P<0.01.