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. 2020 Mar 31;45(6):1888–1908. doi: 10.3892/ijmm.2020.4560

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Akt activation inhibition on the mitochondrial and cytosolic levels of Hsp90 and associated proteins, the oxidation levels and function of myocardial mitochondria, and different treatments on the serum levels of Hsp70 in the tested mice. (A) Representative western blotting results of mitochondrial Hsp90, Akt, p-Akt, PKM2, Bcl-2 and p-Bcl-2. (B) Representative western blotting results of mitochondrial cyt c, and cytosolic cyt c and caspase-3. (C) Effects of Akt activation inhibition on the oxidative levels of myocardial mitochondria. (D) Effects of Akt activation inhibition on the opening of mPTP, and MMP of myocardial mitochondria, respectively. (E) Effects of different treatments on the serum levels of Hsp70 in the tested mice. The relative abundance of all proteins was normalized to that of β-actin. All the results are expressed as the mean ± SD; n=5. ^*P<0.05 and ^**P<0.01 vs. Con, ^#P<0.05 and ^##P<0.01 vs. ASA + HS, and the comparison between ASA and HS is indicated by ^&P<0.05 and ^&&P<0.01.

Effect of Akt activation inhibition on the mitochondrial and cytosolic levels of Hsp90 and associated proteins, the oxidation levels and function of myocardial mitochondria, and different treatments on the serum levels of Hsp70 in the tested mice. (A) Representative western blotting results of mitochondrial Hsp90, Akt, p-Akt, PKM2, Bcl-2 and p-Bcl-2. (B) Representative western blotting results of mitochondrial cyt c, and cytosolic cyt c and caspase-3. (C) Effects of Akt activation inhibition on the oxidative levels of myocardial mitochondria. (D) Effects of Akt activation inhibition on the opening of mPTP, and MMP of myocardial mitochondria, respectively. (E) Effects of different treatments on the serum levels of Hsp70 in the tested mice. The relative abundance of all proteins was normalized to that of β-actin. All the results are expressed as the mean ± SD; n=5. ^*P<0.05 and ^**P<0.01 vs. Con, ^#P<0.05 and ^##P<0.01 vs. ASA + HS, and the comparison between ASA and HS is indicated by ^&P<0.05 and ^&&P<0.01.