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MM cell apoptosis induced by dinaciclib. (A) RPMI8226 and H929 cells were treated with dinaciclib for 24 h, followed by analysis for apoptosis with Annexin V/PI double staining. (B) RPMI8226 and H929 cells were treated with dinaciclib for 24 h; protein lysates were subjected to immunoblotting with the indicated antibodies. MM, multiple myeloma; PARP, poly (ADP ribose); PI, propidium iodide.
