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. 2020 Mar 26;45(6):1661–1672. doi: 10.3892/ijmm.2020.4553

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Combination of dina and bor shows synergistic effect in MM. (A) CDK5 expression in bone marrow biopsies from MM patients was analyzed by immunohistochemistry. Scale bar, 50 µM. (B) RPMI8226 and H929 cells were treated for 24 h with dina, bor, or dina plus bor and then assessed for viability by using the MTT assay. Isobologram analysis shows the synergistic cytotoxic effect of dina and bor. The graphs (right panel) are derived from the values given in the tables (left panel). CI<1 indicates synergy. MM, multiple myeloma; CDK, cyclin dependent kinase; CI, confidence interval; dina, dinaciclib; bor, bortezomib.