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Effects of metformin treatment on the odontoblastic differentiation of DPCs. DPCs cells were preincubated with Compound C (10 μM) for 1 hour before treatment with metformin. The mRNA expression of DSPP, DMP-1, Runx2, and OCN was analyzed using real-time RT-PCR. Data represent mean ± SD of 3 experiments with triplicates. *P < .05. **P < .001.
