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. Author manuscript; available in PMC: 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr 8;580(7803):402–408. doi: 10.1038/s41586-020-2188-x

Fig. 1 |. Generation of a reference interactome map using a panel of binary assays.

Fig. 1 |

a, Overview of HuRI generation. b, Schematic of the Y2H assay versions. c, Experimental validation. Lit-BM: literature-curated binary PPIs with multiple evidence; RRS: random protein pairs. Error bars are 68.3% Bayesian confidence interval, n = 2,281, 383, 475 (MAPPIT) 1,639, 382, 465 (GPCA). d, Number of PPIs and proteins, detected with each additional screen. e, Fraction of direct contact pairs among five PPI networks. Error bar is standard error of proportion, n = 121, 410, 1,169, 584, 1,211 PPIs. f, Number of PPIs identified over time from screening at CCSB and Lit-BM.