Table 2.
Procedural characteristics of subjects undergoing percutaneous coronary intervention (PCI) randomized to an acute pre-procedural oral load of colchicine or placebo
| Colchicine (n=206) |
Placebo (n=194) |
p-value | |
|---|---|---|---|
| Access site, % | 0.96 | ||
| Radial artery | 179 (86.9) | 167 (86.1) | |
| Femoral artery | 24 (11.7) | 24 (12.4) | |
| Radial and femoral arteries | 3 (1.5) | 3 (1.5) | |
| Number of stents deployed | 1 [1, 2] | 1 [1, 2] | 0.56 |
| Total stent length, mm | 28 [18, 38] | 28 [18, 38] | 0.79 |
| Number of inflations | 6 [4, 8] | 6 [4, 8] | 0.68 |
| Multivessel intervention, % | 25 (12.1) | 21 (10.8) | 0.80 |
| Lesion level characteristics | (n=258) | (n=242) | |
| Pre-procedural TIMI 0/1 flow, % | 13 (5.0) | 19 (7.9) | 0.95 |
| Stent diameter, mm2 | 3.00 [2.50, 3.00] | 2.75 [2.50, 3.00] | 0.59 |
| Maximum pressure on last device, atm | 20 ± 4 | 20 ± 5 | 0.65 |
| Bifurcation, % | 40 (15.5) | 36 (14.9) | 0.89 |
| Heavily calcified, % | 35 (13.6) | 45 (18.6) | 0.63 |
| Tortuous, % | 17 (6.6) | 25 (10.3) | 0.74 |
| Chronic total occlusion, % | 14 (5.4) | 11 (4.5) | 0.86 |
| Lesion length >33 mm, % | 57 (22.1) | 52 (21.5) | 0.77 |
| Thrombus, % | 12 (4.7) | 9 (3.7) | 0.91 |
| Re-stenosis, % | 16 (6.2) | 11 (4.5) | 0.82 |
| (n=206) | (n=194) | ||
| Post-procedural TIMI 3 flow, % | 202 (98.1%) | 193 (99.5%) | 0.37 |
| Successful PCI, % | 203 (98.5) | 190 (97.9) | 0.94 |
| Intra-procedural complication, % | |||
| Abrupt closure | 0 | 1 (0.5) | 0.49 |
| Side branch occlusion | 4 (1.9) | 2 (1.0) | 0.69 |
| Persistent flow reduction | 1 (0.5) | 3 (1.5) | 0.36 |
| Distal embolus | 0 | 1 (0.5) | 0.49 |
| Major dissection | 3 (1.5) | 3 (1.5) | 0.99 |
| Coronary perforation | 0 | 1 (0.5) | 0.49 |
| Any complication | 8 (3.9) | 10 (5.2) | 0.71 |
Continuous data are presented as mean ± standard deviation and compared using two sample t test. Skewed continuous data are presented as median [interquartile range] and compared using Mann-Whitney test. Categorical data are presented as frequency (proportion) and compared using chi-square test, or fisher’s exact test if the cell number is less than 5. For lesion level characteristics, a linear mixed effect model and a logistic mixed effect model were used to account for the effect of individual subjects on continuous and categorical variables, respectively.