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. Author manuscript; available in PMC: 2021 Apr 13.

Published in final edited form as: Cancer Cell. 2020 Apr 13;37(4):569–583.e5. doi: 10.1016/j.ccell.2020.03.011

Table 1.

Clinicopathologic features of rearrangement versus SNV-driven pLGG. See also Table S1, S3.

Characteristic		pLGG Subtype		p-value
		Rearrangement	SNV
Number
	N	265	182
Grade
	I	216 (88%)^*	97 (66%)^*	<0.0001
	II	30(12%)^*	50 (34%)^*	<0.0001
Sex
	Male	130 (49%)	98 (54%)	0.337
	Female	135 (51%)	84 (46%)	0.337
Age at Diagnosis
	Under 10	185 (70%)	83 (46%)	<0.0001
	Over 10	80 (30%)	99 (54%)	<0.0001
	Mean	7.6 ±4.8	10.1 ±5.1
	Median	6.6(0.5–18.9)	10.9(0.2–18.9)
Extent of Resection
	GTR	137 (52%)	76 (44%)	0.078
	NoGTR	127 (48%)	96 (56%)	0.078
Location
	Cerebral Hemisphere	86 (32%)	97 (53%)	<0.0001
	Midline	75 (28%)	72 (40%)
	Cerebellum	104 (40%)	13 (7%)
Progression
	Progressed	67 (27%)	80 (46%)	<0.0001
	Stable	184 (73%)	94 (54%)	<0.0001
	5-year PFS	70.6%	51.4%
	10-year PFS	59.8%	30.0%
Outcome
	Dead	7 (3%)	24(13%)	<0.0001
	Alive	249 (97%)	155 (87%)
	5-year OS	97.8%	91.2%
	10-year OS	97.8%	88.1%

Values are displayed as raw counts and the percentage of the group.

^*

denotes categories with omitted samples (LGG, NOS was not assigned a histological grade).