TABLE 3.
Clinicopathologic and perioperative characteristics across multiple CRS-HIPEC procedures
| Variable | First CRS-HIPEC (n = 1294) |
Second CRS-HIPEC (n = 125) |
Third CRS-HIPEC (n = 18) |
Fourth CRS-HIPEC (n = 3) |
|
|---|---|---|---|---|---|
| Clinicopathologic and perioperative charactristics | |||||
| Diagnosis; n (%) | Appendix | 641 (49.5) | 78 (62.4) | 15 (83.3) | 2 (66.7) |
| Colorectal | 389 (30.1) | 29 (23.2) | 2 (11.1) | 0 | |
| Mesothelioma | 157 (12.1) | 15 (12) | 0 | 0 | |
| Ovarian | 107 (8.3) | 3 (2.4) | 1 (5.6) | 1 (33.3) | |
| Combined tumor grade; n (%) | Low | 339 (29.2) | 41 (34.5) | 10 (58.8) | 1 (33.3) |
| Intermediate | 481 (41.5) | 55 (46.2) | 5 (29.4) | 2 (66.7) | |
| High | 340 (29.3) | 23 (19.3) | 2 (11.8) | 0 | |
| Appendix tumor grade; n (%) | Grade G1 | 309 (54.6) | 39 (54.9) | 10 (66.7) | 1 (50) |
| Grade G2 | 156 (27.6) | 26 (36.6) | 4 (26.7) | 1 (50) | |
| Grade G3 | 101 (17.8) | 6 (8.5) | 1 (6.7) | 0 | |
| Colorectal tumor grade; n (%) | Well-diff | 21 (7.5) | 1 (3.6) | 0 | 0 |
| Mod-diff | 168 (60) | 16 (57.1) | 0 | 0 | |
| Poorly-diff | 89 (31.8) | 11 (39.3) | 1(100) | 0 | |
| Mesothelioma tumor grade; n (%) | Low | 14 (9.2) | 0 | 0 | 0 |
| Intermediate | 121 (79.6) | 10 (76.9) | 0 | 0 | |
| High | 17 (11.2) | 3 (23.1) | 0 | 0 | |
| Ovarian tumor grade; n (%) | Low | 11 (10.3) | 0 | 0 | 0 |
| Intermediate | 10 (9.3) | 1 (33.3) | 1 (100) | 1 (100) | |
| High | 86 (80.4) | 2 (66.7) | 0 | 0 | |
| CC-0 resection; % | 66.5 | 61.9 | 70.6 | 100 | |
| CC-0/1 resection; % | 93.3 | 90.3 | 94.1 | 100 | |
| PCI; mean (SD) | 16.5 (8.8) | 13.3 (6.9) | 15.6 (9.2) | 18 (14.1) | |
| Major in-hospital CDC grades 3–4 complications; % | 24.2 | 24.3 | 29.4 | 50 | |
| Progression-free survival; mo (95% CI) | |||||
| Overall (all diagnoses) | 13.7 (12.6, 14.9) | 13.7 (11.5, 15.9) | 19.7 (11.3, 28.1) | – | |
| Appendix cancer | 21.2 (18.7, 23.7) | 19.6 (10.2, 28.9) | – | – | |
| Colorectal cancer | 10.4 (9.1, 11.7) | 9.1 (3.9, 14.3) | – | – | |
| Mesothelioma | 13.7 (9.4, 18.1) | 10.6 (5.5, 15.8) | – | – | |
| Ovarian cancer | 14.3 (8.3, 20.2) | 8.1 (0, 16.4) | – | – | |
| Combined tumor grade | Low | 40.4 (30.5, 50.3) | 28.9 (7.6, 50.3) | 19.6 (8.7, 30.6) | – |
| Intermediate | 13.3 (11.8, 14.8) | 12.2 (9.4, 14.9) | – | – | |
| High | 10.5 (9.0, 11.9) | 8.6 (3.7, 13.6) | 6.5 (–, –) | – | |
| Appendix tumor grade | Grade G1 | 39.9 (30.1, 49.9) | 40.1 (13.5, 66.5) | 19.7 (8.8, 30.6) | – |
| Grade G2 | 13.9 (11.0, 16.9) | 13.7 (8.6, 18.8) | – | – | |
| Grade G3 | 11.6 (7.4, 15.7 | 8.6 (0, 18.3) | 6.5 (–, –) | – | |
| Colorectal tumor grade | Well-diff | 16.8 (6.5, 27.0) | – | – | – |
| Mod-diff | 11.0 (8.3, 13.8) | 10.9 (6.3, 15.6) | – | – | |
| Poorly-diff | 8.7 (6.8, 10.5) | 6.7 (5.5, 7.8) | 13.9 (–, –) | – | |
| Mesothelioma tumor grade | Low | 88.9 (–, –) | – | – | – |
| Intermediate | 14.9 (11.1, 18.7) | 10.5 (0, 24.6) | – | – | |
| High | 6.2 (3.2, 9.1) | 14.1 (–, –) | – | – | |
| Ovarian tumor grade | Low | 45.7 (14.6, 76.8) | – | – | – |
| Intermediate | 28.0 (24.2, 31.8) | 27.3 (–, –) | – | – | |
| High | 11.2 (8.8, 13.6) | 3.0 (–, –) | – | – | |
CRS-HIPEC cytoreductive surgery-hyperthermic intraperitoneal chemoperfusion; CC completion of cytoreduction score; CDC Clavien-Dindo classification; PCI peritoneal cancer index