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. Author manuscript; available in PMC: 2021 Apr 6.
Published in final edited form as: Dev Cell. 2020 Mar 12;53(1):86–101.e7. doi: 10.1016/j.devcel.2020.02.006

Figure 7. Model for centriole-nuclear docking via proximal PCM restriction.

Figure 7.

(A) During normal sperm development, proximal centriolar PCM (green) nucleates MTs (black) that capture the nucleus (blue). This capture is likely mediated by dynein motors tethered to the nuclear surface that drive centriole movement during Nuclear Search. Proper Nuclear Search then leads to Nuclear Attachment prior to axoneme (purple) elongation. (B) When PCM is not proximally restricted, MTs emanate from the entire length of the centriole. These centrioles undergo proper Nuclear Search, but adopt an improper angle relative to the nuclear surface and fail to properly undergo Nuclear Attachment (red). Subsequently, the centriole losses its connection with the nucleus, resulting in decapitation (red).