Table 1.
Demographics and clinicopathologic characterisitcs of patients with uterine leiomyosarcoma.
| Cetegory | Trainning cohort (n=1016) | Validation cohort (n=432) | Total cohort (n=1448) | P |
|---|---|---|---|---|
| No. of patients (%) | No. of patients (%) | No. of patients (%) | ||
| Age(y) | 0,667 | |||
| <51 | 381 (37.5%) | 169 (39.1%) | 550 (38.0%) | |
| 51–58 | 257 (25.3%) | 113 (26.2%) | 370 (25.5%) | |
| >58 | 378 (37.2%) | 150 (34.7%) | 528 (36.5%) | |
| Race | 0,484 | |||
| White | 712 (70.1%) | 316 (73.1%) | 1028 (71.0%) | |
| Other* | 109 (10.7%) | 40 (9.3%) | 149 (10.3%) | |
| Black | 195 (19.2%) | 76 (17.6%) | 271 (18.7%) | |
| Year at diagnosis | 0,119 | |||
| 2004–2009 | 472 (46.5%) | 220 (50.9%) | 692 (47.8%) | |
| 2010–2015 | 544 (53.5%) | 212 (49.1%) | 756 (52.2%) | |
| Grade** | 0,854 | |||
| Low | 184 (18.1%) | 80 (18.5%) | 264 (18.2%) | |
| High | 832 (81.9%) | 352 (81.5%) | 1184 (81.8%) | |
| Stage | 0,239 | |||
| I | 506 (49.8%) | 239 (55.3%) | 745 (51.5%) | |
| II | 103 (10.1%) | 42 (9.7%) | 145 (10.0%) | |
| III | 106 (10.5%) | 43 (10.0%) | 149 (10.3%) | |
| IV | 301 (29.6%) | 108 (25.0%) | 409 (28.2%) | |
| Tumor size (mm) | 0,248 | |||
| <70 | 264 (26.0%) | 123 (28.5%) | 387 (26.7%) | |
| 70–140 | 473 (46.5%) | 208 (48.1%) | 681 (47.0%) | |
| >140 | 279 (27.5%) | 101 (23.4%) | 380 (26.3%) | |
| Surgery type | 0,45 | |||
| Hysterectomy | 953 (93.8%) | 412 (95.4%) | 1365 (94.3%) | |
| Pelvic exenteration | 16 (1.6%) | 4 (0.9%) | 20 (1.3%) | |
| No surgery | 47 (4.6%) | 16 (3.7%) | 63 (4.4%) | |
| Lymphadenectomy | 0,938 | |||
| Yes | 360 (35.4%) | 154 (35.6%) | 514 (35.5%) | |
| No | 656 (64.6%) | 278 (64.4%) | 934 (64.5%) | |
| Radiotherapy | 0,787 | |||
| Yes | 203 (20.0%) | 89 (20.6%) | 292 (20.2%) | |
| No | 813 (80.0%) | 343 (79.4%) | 1156 (79.8%) | |
| Chemotherapy | 0,386 | |||
| Yes | 498 (49.0%) | 201 (46.5%) | 699 (48.3%) | |
| No | 518 (51.0%) | 231 (53.5%) | 749 (51.7%) |
*
American Indian/Alaskan Native, Asian/Pacific Islander;
**
Low: Grade I (well differentiated) and Grade II (moderately differentiated); High: Grade III (poorly differentiated) and Grade IV (undifferentiated anaplastic);
***
Total/simple/pan/radical hysterectomy with or without removal of adnexa.