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. 2020 Mar 30;56(6):1429–1441. doi: 10.3892/ijo.2020.5031

Figure 2.

Figure 2

Sensitivity of MEL-XY3 and MEL-XY3 SUR cells to epigenetic inhibitors. Viability was determined with a CellTiter-Glo assay after 72 h of drug treatment. DNA methyltransferase (decitabine), bromodomain and extra-terminal motif inhibitors (IBET151, OTX-015, JQ-1), enhancer of zeste homolog 2 (GSK126, EPZ-6438), myeloid chronic leukaemia-1 (S63845), cyclin-dependent kinase 9 (CDKI-73) and histone deacetylase inhibitors (panobinostat, SAHA, NaB, TSA, tubacin, MGCD0103, MC1568) were assayed. Representative inhibition curves of 2 independent experiments are shown. Lines represent the nonlinear regression curve fit. Red, parental cells; blue, SUR cells. NaB, sodium butyrate; SUR, surviving cells following long-term PLX4032 treatment; TSA, trichostatin A.