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. 2020 Mar 30;56(6):1429–1441. doi: 10.3892/ijo.2020.5031

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Copyright: © Rowdo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Sensitivity of SUR melanoma cell lines to MGCD0103. (A) Sensitivity to MGCD0103 of parental (red) and SUR (blue) cells obtained from BRAF-mutated melanoma cell lines. Viability was determined after 72 h of drug treatment. Lines represent the nonlinear regression curve fit. Percentage of Annexin V⁺ apoptotic cells after 72 h treatment with 10 µM PLX4032, 2 µM MGCD0103 or combined treatment is shown for (B) MEL-XX12, (C) MEL-XX12 SUR, (D) MEL-XY13, (E) MEL-XY13 SUR, (F) MEL-XX15, (G) MEL-XX15 SUR, (H) MEL-XY3 SURPLXGDC and (I) MEL-XY3 RES cells. ^*P<0.05, ^**P<0.01, ^***P<0.001. RES, resistant to PLX4032; SUR, surviving cells following long-term PLX4032 treatment; SURPLXGDC, cells that survive long-term PLX4032 and GDC-0973 treatment.