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. 2017 Aug 25;34(2):122–129. doi: 10.36141/svdld.v34i2.5369

Fig. 1.

Fig. 1.

Proposed mechanisms of action of soluble IL-2 receptor. A) Sequestration of IL-2 from the heterotrimeric IL-2 receptor by sIL-2R. As discussed above the affinity of sIL-2R for IL-2 in comparison to the affinity of the heterotrimeric IL-2 receptor argues against this mechanism. B) Sequestration of IL-2 from the intermediate affinity IL-2 receptor by sIL-2R. C) sIL-2R competes with plasma enzymes for IL-2 resulting in prolonged IL-2 half-life. D) sIL-2R binding to IL-2 increases the affinity of IL-2 for the intermediate affinity receptor. (s)IL-2Rα: red; IL-2Rβ: purple; IL-2Rγ: blue; IL-2: purple sphere; serum protease: black sphere.