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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: HPB (Oxford). 2019 Mar 14;21(10):1344–1353. doi: 10.1016/j.hpb.2019.01.019

Figure 1. Fibrotic liver tissue with peri-portal inflammation and collagen deposition demonstrates lower electrical resistivity than non-fibrotic liver tissue.

Figure 1.

(A) Hematoxylin and eosin (H&E) and Sirius Red histologic staining of control non-fibrotic and fibrotic liver tissue. After 4 weeks of 0.1% DDC diet, mice develop peri-portal inflammatory infiltrates (arrows) and collagen deposition with portal-portal bridging fibrosis (arrowheads). Magnification 4x. Scale bar = 500μm for all images. (B) Baseline resistivity is significantly lower in fibrotic liver compared to control non-fibrotic liver. Liver tissue resistivity at 10kHz was determined in control mice (n=27) and mice fed a 0.1% DDC diet for 4 weeks (n=21). ***p<0.001 by Student’s t-test.