TABLE 65-4.

Lysosomal Storage Diseases of Dogs and Cats

DISEASE	ENZYME DEFICIENCY	BREEDS AFFECTED	WHITE BLOOD CELL ABNORMALITIES	CLINICAL SIGNS
Mannosidosis	α-d-Mannosidase	English springer spaniel DSH, Persian cat	Lymphocyte, neutrophil, eosinophil, monocyte cytoplasmic vacuolization	Neurological and skeletal abnormalities Retarded growth Facial dysmorphism (flattened features)
Fucosidosis	α-l-fucosidase	English springer spaniel	Lymphocyte vacuolization	Behavioral changes Ataxia Hearing and vision loss
MPS I	α-l-iduronidase	Plott hound DSH cats	Basophilic to metachromatic (pink-purple) neutrophil cytoplasmic granules Lymphocyte granulation or vacuolization	Skeletal abnormalities Facial dysmorphism Dwarfism Corneal opacities Neurologic abnormalities
MPS VI	Arylsulfatase B	Siamese and DSH cats Miniature pinscher	See MPS I	See MPS I
MPS VII	β-Glucuronidase	Dogs, cats	See MPS I	See MPS I
GM1 gangliosidosis	β-d-Galactosidase	Siamese, DSH cats Beagle, English springer spaniel, Portuguese water dog, mixed breed dog	Lymphocyte vacuolization	Ataxia Visual deficits
GM2 gangliosidosis	β-d- Hexosaminidase	Korat and DSH cats Japanese spaniel	Neutrophil granulation Lymphocyte and/or eosinophil vacuolization	Corneal clouding Muscle wasting Cerebral and/or cerebellar dysfunction

DSH, Domestic short hair; MPS, mucopolysaccharidosis.