TABLE 13-6.
Chemotherapy Protocols for Lymphoma in Ferrets
| Protocol 1*47 | |||
|---|---|---|---|
| Week | Day | Drug | Dosage |
| 1 | 1 | Prednisone | 1 mg/kg PO q12h continued throughout treatment |
| 1 | Vincristine | 0.12 mg/kg IV | |
| 3 | Cyclophosphamide | 10 mg/kg PO, SC | |
| 2 | 8 | Vincristine | 0.12 mg/kg IV |
| 3 | 15 | Vincristine | 0.12 mg/kg IV |
| 4 | 22 | Vincristine | 0.12 mg/kg IV |
| 24 | Cyclophosphamide | 10 mg/kg PO, SC | |
| 7 | 46 | Cyclophosphamide | 10 mg/kg PO, SC |
| 9 | Prednisone | Gradually decrease dose to 0 over 4 wk | |
| Protocol 2**33 | ||
|---|---|---|
| Week | Drug | Dosage |
| 1 | Vincristine | 0.07 mg/kg IV |
| Asparaginase | 400 IU/kg IP | |
| Prednisone | 1 mg/kg PO q24h, continued throughout therapy | |
| 2 | Cyclophosphamide | 10 mg/kg SC |
| 3 | Doxorubicin | 1 mg/kg IV |
| 4-6 | Same as weeks 1-3, but discontinue asparginase | |
| 8 | Vincristine | 0.07 mg/kg IV |
| 10 | Cyclophosphamide | 10 mg/kg SC |
| 12 | Vincristine | 0.07 mg/kg IV |
| 14 | Methotrexate | 0.5 mg/kg IV |
| Protocol 3***47 | |
|---|---|
| Drug | Dosage |
| Doxorubicin | 1 mg/kg IV q21 days for up to 5 treatments |
| Prednisone# | 1 mg/kg PO q24h or divided q12h |
*
Check CBCs weekly during therapy, and every 3 months posttherapy with examination.
**
Continue protocol in sequence biweekly after week 14.
***
May be used for recurrence of disease following remission.
#
Optional as concurrent therapy.
From Brown SA: Ferrets: neoplasia. In Hillyer EV, Quesenberry KE, editors: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery, Philadelphia, 1997, WB Saunders. From Rosenthal KL: Ferrets, Vet Clin North Am: Small Anim Pract 24(1):1-23, 1994. From Brown SA: Ferrets: neoplasia. In Hillyer EV, Quesenberry KE, editors: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery, Philadelphia, 1997, WB Saunders.