. 2009 May 15:1003–1069. doi: 10.1016/B978-032304841-5.50053-4

Table 51-19.

Meta-Analyses of Randomized Controlled Trials of Selective Digestive Decontamination

Study, yr	No. of RCTs included	Description	Pneumonia Point Estimate OR or RR (95% CI)	Mortality Point Estimate OR or RR (95% CI)
Vandenbroucke, 1991⁵⁰²	6	Medical and surgical patients	0.12 (0.08-0.19)	0.70 (0.45-1.09)

SDD Trialists Collaborative Group, 1993⁵⁰³	22	Medical and surgical patients	0.37 (0.31-0.43)	0.90 (0.79-1.04)

Kollef, 1994⁵⁰⁴	16	Medical and surgical patients	0.28 (0.21-0.38)	0.90 (0.74-1.1)

Heyland et al, 1994⁵⁰⁵	25	Medical and surgical patients	0.46 (0.39-0.56)	0.87 (0.79-0.97)

Hurley et al, 1995⁵⁰⁶	26	Medical and surgical patients	0.35 (0.30-0.42)	0.86 (0.74-0.99)

D'Amico et al, 1998⁵⁰⁷	33	Medical and surgical patients	0.35 (0.29-0.41)	0.88 (0.78-0.98)

Nathens et al, 1999⁵⁰⁸	21	Medical and surgical patients	Medical: 0.45 (0.33-0.62)	Medical: 0.91 (0.71-1.18)
			Surgical: 0.19 (0.15-0.26)	Surgical: 0.70 (0.52-0.93)

Safdar et al, 2004⁵⁰⁹	4	Liver transplant patients	0.88 (0.73-1.09)^*	0.82 (0.22-2.45)

Liberati et al, 2004⁵¹⁰	36	Medical and surgical patients	0.35 (0.29-0.41)	0.78 (0.68-0.89)

Silvestri et al, 2005⁵¹¹	42	Medical and surgical patients	0.30 (0.17-0.53)^†	NR

Silvestri et al, 2007⁵¹²	51	Medical and surgical patients	0.73 (0.59-0.90)^‡	0.80 (0.69-0.94)

Overall infection.

^†

Fungal infections.

^‡

Bloodstream infection.