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. 2010 Dec 29:26–455. doi: 10.1016/B978-0-443-07151-5.50005-6

Table 3.105.

Clinical features of HL/NHL

HL NHL
Incidence 2.4 per 1 00 000 annually 8.2 per 1 00 000; more common in individuals with AIDS
Age 2 peaks: early adulthood and again later in the elderly

  • Classically seen in the elderly

  • More common in younger age groups since the advent of HIV/AIDS
Symptoms/signs
  • Lymphadenopathy
    • –
      spread is contiguous
    • –
      in early disease, the nodes may fluctuate in size
    • –
      ± alcohol related pain

  • Hepatosplenomegaly

  • General malaise

  • Severe itching

  • Herpes zoster (marker of depression of cell-mediated immunity)
  • Lymphadenopathy
    • –
      spread is not contiguous
    • –
      often presents as disseminated disease
    • –
      predilection for the GIT and CNS

  • High grade disease results in fever, anorexia, weight loss

  • Nodal pressure/extranodal disease may result in:
    • –
      superior vena cava obstruction
    • –
      abdominal obstruction
    • –
      back pain
    • –
      bone pain
    • ±
      signs of autoimmune haemolysis