Table 3.42.
Most commonly used antidepressants
| Class | Abbreviation | Mechanism of action | Drug | Side effects |
|---|---|---|---|---|
| Monoamine oxidase inhibitors | MAOI | Inhibit MAO-A | Moclobemide | |
| Tricyclic antidepressants | TCA | Block reuptake of Nor & 5HT |
|
Sedation |
| Selective serotonin reuptake inhibitors | SSRI | Block reuptake of 5HT |
|
Fewer adverse effects |
| Selective norepinephrine reuptake inhibitors | SNRI | Block reuptake of Nor & 5HT | Venlafaxine | |
| Noradrenaline reuptake inhibitor | NARI | Block reuptake of Nor | Reboxetine | |
| Noradrenergic and specific serotonergic antidepressant | NASSA | Block reuptake of Nor, 5HT2 & 5HT3 | Mirtazapine | |
| Serotonin (5-hydroxytryptamine) antagonists | 5HT | 5HT antagonists | Nefazodone | |