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. 2010 Dec 29:26–455. doi: 10.1016/B978-0-443-07151-5.50005-6

Table 3.53.

Infective endocarditis prophylaxis and dental procedures

Cardiac risk factors for antibiotic prophylaxis Dental procedures requiring antibiotic prophylaxis Antibiotic regimens for endocarditis prophylaxis
Previous infective endocarditis All dental procedures involving dento-gingival manipulation Amoxicillin 3 g orally one hour before the dental procedure: ≥5 < 10 years of age 1.5 g < 5 years of age 750 mg
Cardiac valve replacement surgery i.e. mechanical or biological prosthetic valves

  • If allergic to penicillin:

  • Clindamycin 600 mg orally one hour before the dental procedure:

  • ≥5 < 10 years of age 300 mg < 5 years of age 150 mg
Surgically constructed systemic or pulmonary shunt or conduit

  • Patients allergic to penicillin or unable to swallow capsules:

  • Azithromycin 500 mg orally one hour before the dental procedure:

  • ≥5 < 10 years of age 300 mg < 5 years of age 200 mg

Based on the recommendations of the British Society for Antimicrobial Chemotherapy (BSAC April 2006; www.bsac.org.uk/_db/_documents/ENDOCARDITIS.doc; J Antimicrobial Chemo, 2006. doi:10.1093/jac/dk1121).