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The site of maximum uptake of an inhaled gas is dependent upon its solubility. Thus, ammonia, sulphur dioxide and formaldehyde, which are highly soluble, have their major impact on the upper respiratory tract and trachea whereas oxygen, phosgene (COCl2) and nickel carbonyl (Ni(CO)4), which are less soluble, are taken up in the alveoli, where their toxicity is mainly experienced.
