Table 2. Top 10 hubs of the RA map.
| RA map nodes | Node degree | Role | Reference |
|---|---|---|---|
| NFKB | 28 | Implicated in RA and inflammation | (92, 93) |
| Inflammation | 14 | A major characteristic of RA | (1, 66) |
| AKT | 13 | Regulates apoptosis in RA | (94, 95) |
| Cell chemotaxis/recruitment/infiltration | 13 | Implicated in RA | (96, 97) |
| JUN | 13 | Implicated in RA | (98, 99) |
| MAPK1 | 12 | Implicated in RA | (100, 101) |
| RAC1,2 | 12 | Implicated in RA | (102, 103) |
| Cell growth/survival | 11 | Major characteristic of RA | (66, 85) |
| Osteoclastogenesis | 10 | Results in bone damage in RA | (74, 104) |
| TP53 | 9 | Involved in the apoptosis pathway implicated in RA | (105, 106) |