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. 2020 Apr 20;15(4):e0231775. doi: 10.1371/journal.pone.0231775

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© 2020 Zhang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A~C) A 35-year -old man was found to have a solid nodule in the left lobe of his thyroid. (A) The conventional two-dimensional image showed the nodule had three malignant indicators (solid, markedly hypoechoic, and microcalcifications). (B) CEUS image showed high enhancement of the nodule, indicating that the nodule was benign. (C) The pathological result revealed this lesion was a nodular goiter. (D~F) A 42-year-old woman was found to have a solid nodule in her left thyroid lobe. (D) The conventional two-dimensional image showed the nodule had two malignant indicators (solid and irregular margin). (E) CEUS image showed low enhancement of the nodule, indicating that the nodule was malignant. (F) The pathological result revealed this lesion was a thyroid papillary carcinoma [15]. From Zhang et al. (2017) Usefulness of combined use of contrast-enhanced ultrasound and TI-RADS classification for the differentiation of benign from malignant lesions of thyroid nodules. Eur Radiol 27: 1527–1536. doi: 10.1007/s00330-016-4508-y.