Table 6.
Before Carrageenan | Increase paw volume after 3 h |
Increase paw volume after 5 h |
||||||
---|---|---|---|---|---|---|---|---|
Group (n = 6) | Dose (mg/kg) | Mean ± SE | Mean ± SE | Net | % Inhibition | Mean ± SE | Net | % Inhibition |
Only carrageenan | 1.04 ± 0.02 | 1.68 ± 0.01*** | 0.63 ± 0.01 | 1.65 ± 0.01*** | 0.61 ± 0.02 | Compound 3 | ||
Compound 3 | 150 | 1.02 ± 0.02 | 1.34 ± 0.02*** | 0.31 ± 0.03*** | 50.52 | 1.33 ± 0.01*** | 0.30 ± 0.02*** | 50.54 |
Sulindac | 100 | 1.03 ± 0.03 | 1.26 ± 0.03** | 0.22 ± 0.01*** | 65.18 | 1.25 ± 0.03*** | 1.25 ± 0.03*** | 65.02 |
All values represent mean ± SEM. ANOVA, followed by Dunnett’s multiple comparison test.
**p < 0.01, ***p < 0.001.