Table 2.

In vitro antiproliferative activities of 2–(3-((-pyrimidin-2-yl)amino)benzoyl) hydrazine-1-carboxamide derivatives (Series B) on two selected cancer cell lines. ^a

Compounds	R1	R2	X	IC50[μM]
				HepG2	A549
7a	4-Pyridyl	t-Buty	O	14.37 ± 0.26	31.63 ± 1.50
7b	4-Pyridyl	Cyclopentyl	O	>40	30.24 ± 1.48
7c	3-Pyridyl	t-Butyl	O	31.45 ± 0.44	>40
7d	3-Pyridyl	n-Butyl	O	>40	>40
7e	3-Pyridyl	2,4-dimethoxyphenyl	O	>40	>40
7f	2-Pyridyl	n-Butyl	O	>40	30.59 ± 1.48
7A	4-Pyridyl	Benzyl	S	14.96 ± 0.22	34.43 ± 1.53
7B	3-Pyridyl	Benzyl	S	17.86 ± 0.28	>40
7C	2-Pyridyl	Phenyl	S	17.45 ± 0.34	>40
7D	2-Pyridyl	Benzyl	S	20.23 ± 0.08	>40

^aData are means ± SD of triplicate experiments.