Table 5.

Methodological quality assessment of diagnostic accuracy studies with QUADAS-2.

	Risk of Bias				Applicability Concerns
Author and Year	Patient Selection	Index Test	Reference Standard	Flow and Timing	Patient Selection	Index Test	Reference Standard
Forrester 1999[19]	?	?	?	?	☹	☹	?
Montemerani 1994[28]	☺	☹	☺	?	☺	?	?
Katayama 1990[25]	☹	☹	☺	?	☺	?	?
Stevens 1971[12]	☺	?	?	☺	☺	☺	?
Mathews 1969[13]	☹	☺	?	☺	☺	☺	?
Uitvlugt 1988[20]	☺	?	?	?	☺	☺	?

☺= low risk; ☹= high risk; ? = unclear risk