Table 3.

Activity of ebselen on targets from pathogen.

Target	IC50（µM）	Covalent	Reference
Cryptosporidium parvum glucose-6-phosphate isomerase	8.33	Yes	Eltahan et al.46
Tumor marker endothelial 8 and protective antigen interaction	1.7	Yes	Cryan et al.37
Trypanosoma brucei hexokinase 1	0.05	Yes	Gordhan et al.47
Escherichia coli thioredoxin reductase	0.52 (Ki)	Yes	Lu et al.48
C-terminal domain of HIV-1 capsid	0.047	Yes	Thenin-Houssier et al.39
Bacillus anthracis thioredoxin reductase	1	ND	Gustafsson et al.49
Clostridium difficile cysteine protease domain	0.0069	Yes	Bender et al.50
New Delhi metallo-β-lactamase	0.38	Yes	Chiou et al.51
Mycobacterium tuberculosis antigen 85	0.063	Yes	Favrot et al.52
Hepatitis C Virus NS3 Helicase-Nucleic Acid interaction	1.1/0.9	Yes	Mukherjee et al.53
Cryptosporidium parvum Inosine 5′-monophosphate dehydrogenase	0.71	Yes	Sarwono et al.54
Pseudomonas aeruginosa Diguanylate Cyclases	5	Yes	Lieberman et al.55