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. 2020 Mar 26;7(1):e000368. doi: 10.1136/bmjgast-2019-000368

Table 3.

Proportion of patients with normal and abnormal liver enzyme levels at each study visit

Laboratory value Baselinea 12 weeksb 24 weeksc
Alanine aminotransferase (U/L) n=2843 n=2697 n=2764
 Normal (M<41, F<33) 1028 (36.2) 1427 (52.9) 2095 (75.8)
 Abnormal (1–2 times upper limit) 1286 (45.2) 1127 (41.8) 622 (22.5)
 >2 times upper limit 529 (18.6) 143 (5.3) 47 (1.7)
Aspartate aminotransferase (U/L) n=2843 n=2696 n=2761
 Normal (M<50, F<35) 1487 (52.3) 1907 (70.7) 2464 (89.2)
 Abnormal (1–2 times upper limit) 1162 (40.9) 754 (28.0) 278 (10.1)
 >2 times upper limit 194 (6.8) 35 (1.3) 19 (0.7)
Gamma-glutamyl transferase (U/L) n=2076 n=1936 n=1964
 Normal (M<49, F<32) 827 (39.8) 1017 (52.5) 1228 (62.5)
 Abnormal (1–2 times upper limit) 928 (44.7) 759 (39.2) 666 (33.9)
 >2 times upper limit 321 (15.5) 160 (8.3) 70 (3.6)

Data are expressed as n (%). Percentages are calculated as n/N.

P value (χ2 test with Benjamini-Hochberg correction for multiple comparisons): b vs a, p<0.001, c vs a, p<0.001, c vs b, p<0.001.

F, female; M, male.