Table 4.

Changes in liver function tests at 24 weeks of the study, according to to the nature and number of comorbidities

		Hypertension	Overweight/obesity	T2DM	Elevated cholesterol
ALT (U/L)	Baseline values	50.3±32.8	52.3±34.7	53.9±31.0	51.4±33.4
	Change from baseline*	−19.7±26.5	−21.6±29.4	−22.0±22.7	−20.8±27.3
AST (U/L)	Baseline values	44.3±27.3	45.1±26.6	46.4±24.9	44.8±26.8
	Change from baseline*	−16.9±21.8	−17.7±21.6	−18.4±19.9	−17.1±21.6
GGT (U/L)	Baseline values	53.7±39.3	52.6±38.0	57.7±38.2	52.3±37.4
	Change from baseline*	−17.6±31.6	−17.9±31.6	−18.7±31.2	−17.2±30.6
		One comorbidity	Two comorbidities	Three comorbidities	Four comorbidities
ALT (U/L)	Baseline values	44.5±30.9	49.7±33.0	52.8±34.2	56.3±33.5
	Change from baseline*	−18.4±28.1	−20.4±28.2	−21.2±28.3	−22.4±23.9
AST (U/L)	Baseline values	38.2±20.5	42.8±23.3	47.1±30.5	47.5±25.6
	Change from baseline*	−14.8±18.2	−16.2±19.3	−18.7±24.3	−17.9±20.3
GGT (U/L)	Baseline values	47.8±39.0	48.8±33.6	56.5±40.7	57.2±39.7
	Change from baseline*	−15.7±33.5	−15.5±28.4	−19.5±32.4	−18.6±32.9

Data are expressed as mean±SD.

*There was a significant decrease in the mean values of the liver function tests (p<0.001 compared with baseline, paired t-test).

ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transferase; T2DM, type 2 diabetes mellitus.