Francisco 2002.

Methods	Randomised double‐blind placebo‐controlled cross‐over trial of 4 different 3‐day treatment periods.
Participants	22 participants: 10 adults with CF, aged 18 ‐ 36 years; 12 children with CF aged 6 ‐ 17 years. One adult dropped out of the study after completing 2 of the 4 treatment arms.
Interventions	4 treatment arms compared to placebo 2x daily: 1. children < 40 kg ‐ ranitidine 5 mg/kg; 2. children < 40 kg ‐ ranitidine 10 mg/kg;2. 3. children > 40 kg and adults ‐ ranitidine 150 mg 4. children > 40 kg and adults ‐ ranitidine 300 mg twice daily. Adults also received omeprazole 20 mg daily as adjuvant therapy to pancreatic enzymes compared with placebo.
Outcomes	Faecal fat absorption.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details of method given.
Allocation concealment (selection bias)	Unclear risk	Not discussed
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as double‐blind, but no further details given.
Incomplete outcome data (attrition bias) All outcomes	Low risk	One adult dropped out of the study after completing 2 of the 4 treatment arms. For 12 of the 96 admissions (12.5%) recognisable errors were made in the protocol. Analyses were performed including and excluding these admissions.