Heijerman 1990.

Methods	Randomised, double‐blind, placebo‐controlled cross‐over trial for 2 successive 14‐day treatment periods.
Participants	8 adults with CF (5 males, 3 females) mean age 28 years, range 21 ‐ 43 years. 1 withdrawal during treatment period with enprostil because of severe diarrhoea and abdominal discomfort.
Interventions	2 groups: 1. oral ranitidine 2x 150 mg; 2. enprostil 2x 35 mcg as adjunct to Pancrease.
Outcomes	Faecal fat, weight, gastrointestinal symptoms.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details of method given.
Allocation concealment (selection bias)	Unclear risk	Not discussed
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as double‐blind in text but no details given.
Incomplete outcome data (attrition bias) All outcomes	Low risk	1 withdrawal during treatment period with enprostil because of severe diarrhoea and abdominal discomfort.