Heijerman 1993.

Methods	Randomised, double‐blind, placebo‐controlled cross‐over trial for successive 14‐day treatment periods.
Participants	11adults with CF (5 males, 6 females), age range 20 ‐ 42 years. There were no withdrawals.
Interventions	2 groups: 1. pancrealipase plus placebo; 2. pancrealipase plus oral omeprazole 20 mg.
Outcomes	Faecal fat, serum trypsin, pancreatic polypeptide, insulin and gastrin, PABA in urine.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details of method given.
Allocation concealment (selection bias)	Unclear risk	Not discussed
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as double‐blinded in text but no further details given
Incomplete outcome data (attrition bias) All outcomes	Low risk	11 participants randomised, data for 11 participants presented, therefore there were no withdrawals.