Robinson 1988.

Methods	Randomised, double‐blind, cross‐over trial for 2 successive 14‐day treatment periods.
Participants	22 children with CF (18 males, 4 females) mean age 4.4 years, range 1.5 ‐ 10.5 years. 2 children withdrew.
Interventions	2 groups: 1. pancrease 4x daily; 2. pancrease plus 100 mcg misoprostol 4x daily.
Outcomes	Faecal fat.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details of method given.
Allocation concealment (selection bias)	Unclear risk	Not discussed.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as double‐blinded in text but no further details given.
Incomplete outcome data (attrition bias) All outcomes	Low risk	2 participants withdrawn due to protracted diarrhoea, 20 completed study.