Weber 1981.

Methods	Randomised, double‐blind placebo‐controlled cross‐over trial for 2 successive 8‐day treatment periods.
Participants	18 children with CF, age range 3 ‐ 13 years. No mention of withdrawals.
Interventions	2 groups: 1. sodium bicarbonate 1 mEq/kg/meal; 2. placebo.
Outcomes	Faecal fat, chymotrypsin, bile acid, faecal weight.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details of method given.
Allocation concealment (selection bias)	Unclear risk	Not discussed.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as double‐blinded in text but no further details given.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No mention of withdrawals.

BSA: body surface area
 CBC: complete blood count
 CF: cystic fibrosis
 CFQ‐R: cystic fibrosis questionnaire ‐ revised
 GSAS: gastroesophageal assessment score
 Hb: haemoglobin
 H. pylori: Helicobacter pylori
 mEq: milliequivalent
 PABA: para‐aminobenzonic acid