Date	Event	Description
10 July 2014	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Group's Trials Register identified a single new reference which has been included in the review (DiMango 2014).
10 July 2014	New citation required but conclusions have not changed	Although a single new abstract was identified which was eligible for inclusion in the review, the limited narrative information provided has not led to any change in the conclusions of this review.
16 February 2012	New citation required but conclusions have not changed	No new references have been added to the review at this update.
16 February 2012	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register did not identify any references potentially eligible for inclusion in this review.
15 April 2010	New search has been performed	A search of the Cystic Fibrosis Trials Register identified two studies potentially eligible for inclusion in the review. One of these has been included (Lubin 1979) and the other has been excluded (Tsang 1994).
13 May 2009	Amended	No changes ‐ republished to fix technical problem.
16 June 2008	Amended	Converted to new review format.
13 June 2008	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register did not identify any references potentially eligible for inclusion in this review.
22 August 2007	Amended	The plain language summary has been re‐drafted in light of the current guidance from The Cochrane Collaboration.
22 August 2007	New search has been performed	A search of the Group's Cystic Fibrosis Trial's Register did not identify any new references which were eligible for inclusion in this review.
16 August 2006	New search has been performed	A search of the Group's Cystic Fibrosis Trial's Register did not identify any new references which were eligible for inclusion in this review.
17 August 2005	Amended	It was decided by the review authors to remove the data analysis that was previously included within the review. It was felt that this analysis was inappropriate and it would be of more benefit to the reader to report the individual trial results narratively under the relevant outcomes.
17 August 2005	New search has been performed	Two trials have been included within the review (Durie 1980; Proesmans 2003). Three trials have been added to the 'Excluded studies' section of the review (Ansaldi‐Balocco 1988; Gow 1981; Stead 1988).
24 February 2004	New search has been performed	A search found two new trials for inclusion in the review (Chung 2000; Francisco 2002). However, we were not able to include any new data.