Carroccio 1992.

Methods	Randomised, double‐blind, placebo‐controlled cross‐over trial for 2 successive 6‐month treatment periods.
Participants	10 children with CF (7 males, 5 females), mean age 12.5 years, age range 7 ‐ 18 years, with persistent steatorrhoea on enzymatic supplements (12 children were originally enrolled, but 2 were excluded).
Interventions	2 groups: 1. usual enzyme therapy plus famotidine 1 mg/kg/day; 2. usual enzyme therapy plus placebo.
Outcomes	Faecal weight, fat absorption, weight and height changes, serum calcium, triglycerides, cholesterol, phosphate, iron, Hb, albumin, Crispin Norman score, Shwachman score.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details of method given.
Allocation concealment (selection bias)	Unclear risk	Not discussed.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as double‐blind in text but no further details given.
Incomplete outcome data (attrition bias) All outcomes	Low risk	12 children were originally enrolled, but 2 were excluded with severe pulmonary infections.