Chung 2000.
Methods | Randomised double‐blind placebo‐controlled cross‐over trial for 2 successive 6‐week treatment periods with 1‐week washout period. | |
Participants | 6 children with CF randomised, 1 excluded because of positive H. pylori. Data from 5 children aged 5 ‐ 12 years. | |
Interventions | 2 groups: 1. placebo; 2. omeprazole 10 mg/day or 20 mg/day depending on weight. |
|
Outcomes | Faecal fat, CBC, SMAC, prealbumin, height, weight, malabsorption symptom checklist, genotype analysis, H. pylori status. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Described as randomised, but no details of method given. |
Allocation concealment (selection bias) | Unclear risk | Not discussed. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Described as double‐blind in text but no further details given. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 1 child excluded because of positive H. pylori, data available from 5 remaining participants. |