TABLE 2.
Mutations identified in genes associated with AMR or the response to stress through WGS analysis of Salmonella antibiotic-resistant variantsa
| Strain | No. of genes with mutations |
AMR-related genes |
Stress response-associated genes |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Complex | Del | Ins | MNP | SNP | Total | Gene | Type | Gene | Type (mutation) | |
| 1-EVOL | 1 | 4 | 4 | 0 | 21 | 29 | crl | Del (Ser35fs) | ||
| rcsC | SNP (Ser394Leu) | |||||||||
| ptsJ | SNP (Pro138Ser) | |||||||||
| cytR | SNP (Asn219Tyr) | |||||||||
| recE-like gene | Complex (SerIleTrp511ArgIleArg) | |||||||||
| recE-like gene | SNP (Ala117Thr), SNP (Val119Ala) | |||||||||
| 2-EVOL | 1 | 1 | 5 | 0 | 46 | 53 | gyrA | SNP (Met86Ile) | uvrB | SNP (Asn624Lys) |
| zntA | SNP (Leu43Pro) | |||||||||
| 3-EVOL | 0 | 2 | 1 | 0 | 18 | 21 | gyrA | SNP (Pro83Ser) | crl | Del (Ser35fs) |
| dacB | SNP (Ala161Val) | hnr | SNP (Leu102Val) | |||||||
| soxR | SNP (Val20Leu) | |||||||||
| 4-EVOL | 1 | 2 | 1 | 0 | 19 | 23 | rpsL | SNP (Lys88Glu) | crl | Del (Ser35fs) |
| dacB | SNP (Ala161Val) | hnr | SNP (Leu102Val) | |||||||
| gppA | Complex (IlePro125MetPro) | |||||||||
a
Complex, the genome contains two or more of the following mutation types: deletion (Del), insertion (Ins), multiple nucleotide polymorphism (MNP), and single nucleotide polymorphism (SNP).