Table 5. Important GRMs: obtained as the set of first 20 GRMs with highest in-degree (I), out-degree (O) and betweenness (B) coefficients.

GRM	Importance	GRM	Importance	GRM	Importance
M119	O, B	M278	O	M384	I
M124	O	M290	B	M392	O
M133	O, B	M300	I	M404	I, B
M142	I, B	M307	I, B	M407	I
M156	O	M319	O, B	M408	O
M168	B	M322	O, B	M414	O
M178	O	M326	I, B	M416	I
M189	O, B	M330	I	M422	I, B
M19	O, B	M331	O	M431	I
M198	B	M337	O	M432	O
M225	B	M362	I	M436	O
M235	I, B	M37	B	M438	I, O
M244	B	M372	I, B	M454	I
M250	O	M374	I, B	M455	I
M265	O	M375	I	M72	I

In-degree (Out-degree) shows the number of GRMs regulating (regulated by) the GRM of interest. Betweenness shows the number of time that a GRM is a bridge between two other GRMs.