Table 1. Average scores for histologic detection of the number of proliferating prostate epithelial cells, presence of reactive stroma and immune cell infiltration in AP, LP, DP and VP sections from psPten–/– mice treated for 8 weeks with vehicle or Rapatar (25 or 5 mg/kg; 15 mice/group).
| Experimental Group | Proliferation | Presence of reactive stroma | Immune cell infiltration | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AP | LP | DP | VP | Total | AP | LP | DP | VP | Total | AP | LP | DP | VP | Total | |
| Vehicle | 1.96 | 1.81 | 2.57 | 1.93 | 8.27 | 1.70 | 1.63 | 1.03 | 1.73 | 5.93 | 1.40 | 1.37 | 1.47 | 1.9 | 6.13 |
| Rapatar 25 mg/kg | 1.21 | 1.32 | 1.72 | 1.12 | 5.37* | 2.07 | 2.10 | 1.37 | 2.0 | 7.53^ | 1.93 | 1.87 | 1.40 | 2.10 | 7.20 |
| Rapatar 5 mg/kg | 1.42 | 1.15 | 1.61 | 1.09 | 5.86* | 1.55 | 2.03 | 1.07 | 1.13 | 5.98 | 1.77 | 1.63 | 1.43 | 1.50 | 6.33 |
“Total” is the sum of the AP, LP, DP and VP scores. *significantly reduced proliferation in both Rapatar groups vs. vehicle group (p < 0.001, one-way ANOVA with Turkey post-hoc comparisons). ^significantly increased presence of reactive stroma in the 25 mg/kg Rapatar group vs. vehicle group (p = 0.03, Student’s t-test). P-values for all other comparisons between groups for a given parameter were > 0.05. Data are presents as mean values.